Drug Development Services
Hit and lead optimization
From discovering active lead compounds to identifying clinical candidate compounds, multiple rounds of molecular structure optimization and property evaluations are essential. ComMedX provides rapid optimization services for lead compounds, leveraging our AI-enhanced drug design, medicinal chemistry, and biological testing platforms. These services greatly accelerate the drug molecule optimization process, reducing the timeline from lead compounds to clinical candidates.
Service offereings
- Applying computational drug design technologies, such as molecular docking based on physical principles and AI models, predicting drug properties, and optimizing lead compounds based on their structures, for rational compound design.
- Our experienced medicinal chemists on the internal pharmaceutical platform utilize parallel synthesis among other techniques to quickly probe focused chemical spaces.
- Systematic in vitro evaluations of synthesized compounds cover biological activity, selectivity, cytotoxicity, and metabolic stability, aiming to identify compounds with superior characteristics.
- For compounds that exhibit exceptional activity and selectivity, further in vivo pharmacokinetic and pharmacodynamic studies are conducted to fully assess their drug-like properties, leading to the selection of clinical candidate compounds.
- Clients receive detailed research reports that include synthesis routes, structural characterization, in vitro and in vivo pharmacological data, and ADME properties, providing robust data support for their upcoming preclinical studies.
Why ComMedX
- AI-Enabled Rational Design: Utilizing computational drug design methods, including those based on physical principles and AI models, to rationally design and optimize lead compounds.
- Integrated One-stop Platform: ComMedX has developed a seamless integration of computational drug design, medicinal chemistry, and biological testing, enhancing the efficiency of molecular optimizations.
- Cost Efficiency: With our rationale-driven integrated platform and extensive R&D experience, we optimize the transition from lead compounds to clinical candidates more quickly and cost-effectively, enhancing our clients’ investment returns.
Business Inquiry
For more information, please send a message to contact@commedx.com
We will get in touch with you as soon as possible.
